The Human Phenotype Project is a large-scale (>13,000 participants) deep-phenotype prospective longitudinal cohort established at the Weizmann Institute to identify novel molecular markers with diagnostic, prognostic and therapeutic value, and to develop prediction models for disease onset and progression. The cohort includes both healthy participants as well as those with approximately 40 distinct diseases, including metabolic disease, neurological disorders, gastrointestinal disease, cardiovascular disease, and various cancer malignancies; with many participants having multiple comorbidities. For each participant, the deep phenotype profile consists of diverse modalities, including imaging (e.g., dual-energy x-ray absorptiometry; DXA, ultrasound, retina scans), time-series (e.g., electrocardiogram, continuous glucose monitoring, and sleep), multi-omics (e.g., transcriptome, genetics, gut microbiome, metabolome and immune system), tabular (blood tests, body measures), and questionnaire and App data types (e.g., lifestyle and nutritional habits).

The Human Phenotype Project aims to support researchers developing the next wave of innovation in human health and disease research. We invite proposals for any analyses of this data and uses of these data. Applicants should articulate the types of data to be used, the analyses that will be performed, and the expected outcomes. Access to the dataset will be given to all applicants regardless of those selected for funding.